Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
Identifieur interne : 003613 ( Main/Exploration ); précédent : 003612; suivant : 003614Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
Auteurs : Christopher A. Desjardins [États-Unis] ; Gustavo C. Cerqueira [États-Unis] ; Jonathan M. Goldberg [États-Unis] ; Julie C. Dunning Hotopp [États-Unis] ; Brian J. Haas [États-Unis] ; Jeremy Zucker [États-Unis] ; Jose M. C. Ribeiro ; Sakina Saif [États-Unis] ; Joshua Z. Levin [États-Unis] ; Lin Fan [États-Unis] ; Qiandong Zeng [États-Unis] ; Carsten Russ [États-Unis] ; Jennifer R. Wortman [États-Unis] ; Doran L. Fink [États-Unis] ; Bruce W. Birren [États-Unis] ; Thomas B. Nutman [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2013.
Abstract
Url:
DOI: 10.1038/ng.2585
PubMed: 23525074
PubMed Central: 4238225
Affiliations:
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Desjardins</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Cerqueira, Gustavo C" sort="Cerqueira, Gustavo C" uniqKey="Cerqueira G" first="Gustavo C." last="Cerqueira">Gustavo C. Cerqueira</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Goldberg, Jonathan M" sort="Goldberg, Jonathan M" uniqKey="Goldberg J" first="Jonathan M." last="Goldberg">Jonathan M. Goldberg</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C. Dunning" last="Hotopp">Julie C. Dunning Hotopp</name><affiliation wicri:level="2"><nlm:aff id="A2">Institute for Genome Science, Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Institute for Genome Science, Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Haas, Brian J" sort="Haas, Brian J" uniqKey="Haas B" first="Brian J." last="Haas">Brian J. Haas</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Zucker, Jeremy" sort="Zucker, Jeremy" uniqKey="Zucker J" first="Jeremy" last="Zucker">Jeremy Zucker</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Ribeiro, Jose M C" sort="Ribeiro, Jose M C" uniqKey="Ribeiro J" first="Jose M. C." last="Ribeiro">Jose M. C. Ribeiro</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Saif, Sakina" sort="Saif, Sakina" uniqKey="Saif S" first="Sakina" last="Saif">Sakina Saif</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Levin, Joshua Z" sort="Levin, Joshua Z" uniqKey="Levin J" first="Joshua Z." last="Levin">Joshua Z. Levin</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Fan, Lin" sort="Fan, Lin" uniqKey="Fan L" first="Lin" last="Fan">Lin Fan</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Zeng, Qiandong" sort="Zeng, Qiandong" uniqKey="Zeng Q" first="Qiandong" last="Zeng">Qiandong Zeng</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Russ, Carsten" sort="Russ, Carsten" uniqKey="Russ C" first="Carsten" last="Russ">Carsten Russ</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Wortman, Jennifer R" sort="Wortman, Jennifer R" uniqKey="Wortman J" first="Jennifer R." last="Wortman">Jennifer R. Wortman</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Fink, Doran L" sort="Fink, Doran L" uniqKey="Fink D" first="Doran L." last="Fink">Doran L. Fink</name><affiliation wicri:level="2"><nlm:aff id="A3">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Birren, Bruce W" sort="Birren, Bruce W" uniqKey="Birren B" first="Bruce W." last="Birren">Bruce W. Birren</name><affiliation wicri:level="2"><nlm:aff id="A1">Broad Institute of MIT and Harvard, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of MIT and Harvard, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name><affiliation wicri:level="2"><nlm:aff id="A3">Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2"><italic>Loa loa</italic>, the African eyeworm, is a major filarial pathogen of humans. Unlike most filariae, <italic>Loa loa</italic> does not contain the obligate intracellular <italic>Wolbachia</italic> endosymbiont. We describe the 91.4 Mb genome of <italic>Loa loa</italic>, and the genome of the related filarial parasite <italic>Wuchereria bancrofti</italic>, and predict 14,907 <italic>Loa loa</italic> genes based on microfilarial RNA sequencing. By comparing these genomes to that of another filarial parasite, <italic>Brugia malayi</italic>, and to several other nematode genomes, we demonstrate synteny among filariae but not with non-parasitic nematodes. The <italic>Loa loa</italic> genome encodes many immunologically relevant genes, as well as protein kinases targeted by drugs currently approved for humans. Despite lacking <italic>Wolbachia, Loa loa</italic> shows no new metabolic synthesis or transport capabilities compared to other filariae. These results suggest that the role played by <italic>Wolbachia</italic> in filarial biology is more subtle than previously thought and reveal marked differences between parasitic and non-parasitic nematodes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klion, Ad" uniqKey="Klion A">AD Klion</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardon, J" uniqKey="Gardon J">J Gardon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Bockarie, M" uniqKey="Bockarie M">M 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C." last="Ribeiro">Jose M. C. Ribeiro</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Desjardins, Christopher A" sort="Desjardins, Christopher A" uniqKey="Desjardins C" first="Christopher A." last="Desjardins">Christopher A. Desjardins</name></region><name sortKey="Birren, Bruce W" sort="Birren, Bruce W" uniqKey="Birren B" first="Bruce W." last="Birren">Bruce W. Birren</name><name sortKey="Cerqueira, Gustavo C" sort="Cerqueira, Gustavo C" uniqKey="Cerqueira G" first="Gustavo C." last="Cerqueira">Gustavo C. Cerqueira</name><name sortKey="Fan, Lin" sort="Fan, Lin" uniqKey="Fan L" first="Lin" last="Fan">Lin Fan</name><name sortKey="Fink, Doran L" sort="Fink, Doran L" uniqKey="Fink D" first="Doran L." last="Fink">Doran L. Fink</name><name sortKey="Goldberg, Jonathan M" sort="Goldberg, Jonathan M" uniqKey="Goldberg J" first="Jonathan M." last="Goldberg">Jonathan M. Goldberg</name><name sortKey="Haas, Brian J" sort="Haas, Brian J" uniqKey="Haas B" first="Brian J." last="Haas">Brian J. Haas</name><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C. Dunning" last="Hotopp">Julie C. Dunning Hotopp</name><name sortKey="Levin, Joshua Z" sort="Levin, Joshua Z" uniqKey="Levin J" first="Joshua Z." last="Levin">Joshua Z. Levin</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name><name sortKey="Russ, Carsten" sort="Russ, Carsten" uniqKey="Russ C" first="Carsten" last="Russ">Carsten Russ</name><name sortKey="Saif, Sakina" sort="Saif, Sakina" uniqKey="Saif S" first="Sakina" last="Saif">Sakina Saif</name><name sortKey="Wortman, Jennifer R" sort="Wortman, Jennifer R" uniqKey="Wortman J" first="Jennifer R." last="Wortman">Jennifer R. Wortman</name><name sortKey="Zeng, Qiandong" sort="Zeng, Qiandong" uniqKey="Zeng Q" first="Qiandong" last="Zeng">Qiandong Zeng</name><name sortKey="Zucker, Jeremy" sort="Zucker, Jeremy" uniqKey="Zucker J" first="Jeremy" last="Zucker">Jeremy Zucker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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